Impact of a Dietary Supplement Containing 1,3-Dimethylamylamine on Blood Pressure and Bloodborne Markers

Impact of a Dietary Supplement Containing 1,3-Dimethylamylamine on Blood Pressure and Bloodborne

Markers of Health - a 10-Week Intervention Study

Warning: This is a information about this study. Complete study about Impact of a Dietary supplement containing 1,3 Dimethylamylamine on Blood pressure and Bloodborne markers of Health, with all information you can read in PDF on this link.

Paul N. Whitehead, Brian K. Schilling, Tyler M. Farney and Richard J. Bloomer

Cardiorespiratory/Metabolic Laboratory, The University of Memphis, Memphis, TN 38152, USA.

Corresponding author email: rbloomer@memphis.edu

DMAA and dietary supplements saftey

While somewhat controversial, 1,3-dimethylamylamine has been suggested to be a component of the Pelargonium graveolens plant;1 a simple aliphatic amine2 with sympathomimetic properties. Aside from 1,3-dimethylamylamine, common chemical names cited for this agent include 2-amino-4-methylhexane, 1,3-dimethylpentylamine, methylhexaneamine, and 4-methyl-2-hexylamine. It is also known by the trademarked name geranamine™ (Proviant Technologies, Inc, 2005: US trademark number: 78542697). 

The use of 1,3-dimethylamylamine is widespread within the dietary supplement industry, in particular as a component of weight loss and pre-workout products. A recent report published by the Human Performance Resource Center (http://www.humanperformanceresourcecenter.org) provides a detailed listing of close to 100 products believed to contain 1,3-dimethylamylamine. While anecdotal reports of improved exercise performance are common, we are aware of only one published experiment designed to investigate the ergogenic properties of 1,3-dimethylamylamine alone or in combination with caffeine,3 which noted little impact on aerobic exercise performance. 

Regardless of actual ergogenic effectiveness, the overall safety of the ingredient needs to be considered. In our recent article in which 1,3-dimethylamylamine was administered alone and in combination with caffeine in a single dosage to healthy men and women,4 we noted that heart rate was unaffected by treatment, but blood pressure was elevated when consuming 1,3-dimethylamylamine—generally in a dose-dependent manner. The peak percent change in systolic (∼20%) and diastolic (∼17%) blood pressure was noted at 60 minutes following ingestion of the combination of 250 mg of caffeine and 75 mg of 1,3-dimethylamylamine.

A second study investigated the blood pressure and heart rate response of 1,3-dimethylamylamine and caffeine alone and in combination (compared to a placebo) in a sample of endurance trained men and women before, during, and following strenuous exercise.3 In this study, heart rate was relatively similar across conditions, and blood pressure was generally highest for caffeine and 1,3-dimethylamylamine alone compared to other conditions. 

Research on the use of 1,3-dimethylamylamine in combination with other ingredients within finished products demonstrated first that, in terms of acute changes in blood pressure and heart rate, dietary supplements containing 1,3-dimethylamylamine result in minimal change in heart rate but do increase systolic blood pressure transiently.

Second, in terms of chronic changes in blood pressure and heart rate, we have noted little or no change in resting measures after a two-week5 or eight-week7 intervention. 

Third, in terms of chronic changes in bloodborne biomarkers of health and safety, we have noted little or no change in measures after a two-week5 or eight-week7 intervention. Collectively, the above findings indicate relative safety of this ingredient, at least with regard to the included outcome measures.

However, due to the transient increase in systolic blood pressure, the need exists to further evaluate the potential for this agent to raise resting blood pressure following a longer period of chronic intake. The present study sought to extend our prior findings related to the use of 1,3-dimethylamylamine in a combined product by using a 10-week intervention trial to determine the change in selected markers of health and safety in a sample of healthy men.

article source: DMAA Research

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What is Dimethylamylamine (DMAA)?

Dimethylamylamine powder

What is Dimethylamylamine - (DMAA)?

Dimethylamylamine is a drug made synthetically in a laboratory. It was originally used as a nasal decongestant. Today, dimethylamylamine is sold as a dietary supplement used for attention deficit-hyperactive disorder (ADHD), weight loss, improving athletic performance, and body building.

Some products claim that dimethylamylamine naturally comes from rose geranium oil. Supplements that contain this ingredient sometimes list rose geranium, geranium oil, or geranium stems on the label. However, laboratory analysis shows that this drug probably does not come from this natural source. It is thought that these manufacturers have artificially added this drug to the supplement rather than obtaining it from a natural source. Dimethylamylamine is considered a drug in Canada is not permitted in dietary supplements or natural health products.

Many athletes take dimethylamylamine to improve performance. However, dimethylamylamine was added to the World Anti-Doping Agency’s prohibited substances list for 2010. Therefore, competitive athletes should avoid taking it.

Due to safety concerns, dimethylamylamine has been temporarily removed from military stores in the US. It has also been banned in New Zealand. Its use has been linked to several reports of serious, life-threatening side effects.

How does it work?

Dimethylamylamine is thought to have stimulant effects similar to decongestants such as pseudoephedrine, ephedrine, and others. Some promoters say that it is a safer alternative to ephedrine. However, there is no scientific information to back up this claim.

Dimethylamylamine - Uses

    Weight loss.

    Athletic performance.

    Body building.

    Other conditions.

Dimethylamylamine is likely unsafe when taken by mouth. Since it is thought to work like a stimulant, there is concern that it might increase the chance of serious side effects such as rapid heartbeat, increase in blood pressure, and increase the chance of having a heart attack or stroke.

In clinical research, taking a product containing dimethylamylamine plus other ingredients seems to increase heart rate and blood pressure.

There have been several reports of dangerous side effects including stroke, a condition called lactic acidosis, heart attack, and death in people who have taken dimethylamylamine.

Special Precautions & Warnings

Pregnancy and breast-feeding: Not enough is known about the use of dimethylamylamine during pregnancy and breast-feeding. Stay on the safe side and avoid use.

High blood pressure: Dimethylamylamine might have stimulant effects and can increase blood pressure. If you have high blood pressure, avoid taking dimethylamylamine.

Glaucoma: Dimethylamylamine might have stimulant effects and cause blood vessels to constrict. This could worsen some types of glaucoma. If you have glaucoma, avoid taking dimethylamylamine.

Irregular heartbeat (heart arrhythmia): Dimethylamylamine might have stimulant effects and can cause a rapid heartbeat. This could worsen heart arrhythmias.

Surgery: Dimethylamylamine might have stimulant effects, so it might interfere with surgery by increasing heart rate and blood pressure. Stop taking dimethylamylamine at least 2 weeks before a scheduled surgery.

Dimethylamylamine (DMAA) Dosing

The appropriate dose of dimethylamylamine depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for dimethylamylamine. 

Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using. 

article source: Webmd

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